An innovative method to measure immunity

T-Cell response measurement: understanding individual immune ability

Until now, antibody tests have been the typical tool used to measure the immune response to SARS-CoV-2. Both antibodies and cellular immune response act in coordination to achieve protection from viral infections.
Hyris solution overcomes the current limitations in detecting specific T Cells, using synthetic peptides to activate T Cells in-vitro. In addition to this, Hyris developed and patented a fast and scalable RT-PCR test to quantify the specific response of T Cells. This innovative and reliable solution has been at the base of a major study published on Nature Biotechnology.

Complete understanding on IMMUNE ABILITY can be achieved only with T-CELLS RESPONSE MEASUREMENT.

Until now, antibody tests have been the typical tool used to measure the immune response to SARS-CoV-2. Both antibodies and cellular immune response act in coordination to achieve protection from viral infections. Antibodies are fundamental for preventing infection, protecting from the disease, while cellular immunity is essential to eliminate virus-infected cells, therefore supporting in fighting the disease itself.

Typically, detection of antigen specific T cells to qualify the cellular immune response is performed by expensive technology, both in terms of costs, equipment and skills required.

Hyris introduces a new bKIT™
for T-Cell testing, to UNDERSTAND and MEASURE
patients' level of CELLULAR IMMUNITY TO SARS-COV-2.

Hyris solution overcomes the current limitations in detecting specific T Cells, using synthetic peptides to activate T Cells in-vitro. In addition to this, Hyris developed and patented a fast and scalable RT-PCR test to quantify the specific response of T Cells. This innovative and reliable solution has been at the base of a major study published on Nature Biotechnology.

Contact us to know more about the latest Hyris tests

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Test Workflow

HYRIS bKIT XACT (SCV2)

SARS-CoV-2 speciﬁc T-cell activation through whole blood peptides treatment

HYRIS bKIT dqTACT

Cyclokine mRNA detection, through the execution of the Real-Time RT-PCR test on the blood previously threated

Hyris solution overcomes the current limitations in detecting specific T Cells, using synthetic peptides to activate T Cells in-vitro. In addition to this, Hyris developed and patented a fast and scalable RT-PCR test to quantify the specific response of T Cells. This innovative and reliable solution has been at the base of a major study published on Nature Biotechnology.

Potential applications

Detecting INDIVIDUAL IMMUNITY to SARS-CoV-2, complementing antibody testing

Support VACCINE R&D to measure actual individual immune response over time;

Support HEALTHCARE PRACTITIONERS in protecting speciﬁc patient categories;

Support VACCINE STRATEGIES deﬁnition for health institutions and policymakers;

Evidence

M. Schwarz et al. Rapid, scalable assessment of SARS-CoV-2 cellular immunity by whole-blood PCR. Nature Biotechnology (2022).

Tan A.T. et al. Rapid measurement of SARS-CoV-2 spike T cell in whole blood from vaccinated and naturally infected individuals. Journal of Clinical Investigation. doi: 10.1172/JCL152379

Le Bert N, Tan AT, Kunasegaran K, Tham CYL, Hafezi M, Chia A et al. SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls. Nature 2020; 584: 457–462.

Tan AT, Lim JM, Le Bert N, Kunasegaran K, Chia A, Qui M et al. Rapid determination of the wide dynamic range of SARS-CoV-2 Spike T cell responses in whole blood of vaccinated and naturally infected. bioRxiv 2021; 2021.06.29.450293

Tan, A. T. et al. Early induction of functional SARS-CoV-2 specific T cells associates with rapid viral clearance and mild disease in COVID-19 patients. Cell Reports 34, 108728 (2021). doi: 10.1016/j.celrep.2021.108728

Le Bert, N. et al. Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infection. J Exp Med 218 (2021).

Future

Hyris CONCEPTUAL INNOVATION is completely disruptive in the detection of the cellular immunity and opens a WIDE RANGE OF APPLICATIONS for understanding the full immune ability.

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